Sometimes there just isn't a cure for what ails you.

After 13 years of marriage, Maura Tierney is looking to divorce her husband, actor-director Billy Morrissette. The couple, who have no children, have been separated since Mar. 7.

The ER star--whose pregnant character, Abby Lockhart, was last seen collapsing in pain during the show's cliffhanger season finale in May--filed her petition Wednesday in Los Angeles Superior Court, citing "irreconcilable differences."

In the beginning, Morrissette and Tierney shared a true Hollywood romance--they met after both being fired from a TV series that was to star Ralph Macchio (but was later scrapped, in case you were wondering). The duo tied the knot in February 1993.

Morrissette, who as an actor had a number of bit parts in shows like Party of Five, Mad About You and Living Single, directed Tierney in the 2001 film Scotland, Pa. His missus played a Lady Macbeth-type villainess (named Pat McBeth, actually) who helps her husband configure a plan to murder his boss. Macbeth-style ironic tragedy ensues.

After her ER shift ended this season, Tierney starred opposite Eric McCormack in the off-Broadway play Some Girls. The 41-year-old actress' film credits include Liar Liar, Primal Fear and Primary Colors, and she starred on NewsRadio from 1995 to 1999. She scored an Emmy nomination for ER in 2001.

Per, Tierney also has two indie films in the works--The Go-Getter, costarring Zooey Deschanel and Jena Malone, and the coming-of-age comedy Diggers, with Paul Rudd and Lauren Ambrose.

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