The two actors were joined by their eldest child, Maddox Jolie-Pitt, as they hastily walked to their chauffeured vehicle.
Angelina sported a signature all-black ensemble, while Pitt opted to wear matching khaki boots, jeans and a jacket for the long flight.
Maddox, who turns 13 later this year, appeared to be in a good mood as he listened to music on his iPod and carried his own bags to the car.
Meanwhile, Universal Pictures debuted a three-minute preview of Jolie's next directorial project, Unbroken.
The first trailer for the film, which tells the story of 1936 Olympian Louis Zamperini, aired during NBC's coverage of the Winter Olympic Games on Sunday night.