Families fight. And when a family as big as the Kardashians gets into it...

Things can get dramatic.

"When you fight with your siblings, you could be ruthless and evil," Khloé Kardashian Odom said recently when the entire family sat down with E!'s Ryan Seacrest for an in-depth interview.

"Nothing is off limits," added Kim Kardashian. "That's just how life is."

For more exclusive sneak-preview footage, tune into E! News tonight at 7 p.m. and 11:30 p.m. And don't miss the answers to all of Ryan's questions when Ryan Seacrest With the Kardashians: An E! News Presentation premieres April 21 at 9 p.m.

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