David Arquette

Hellmuth Dominguez, PacificCoastNews.com

David Arquette's split from Courteney Cox isn't slowing down his after-hours partying.

The newly separated Scream star was spotted out in Hollywood last night living it up with more than one girl.

And former hookup Jasmine Waltz wasn't one of them...

The 39-year-old dad hit up hot spot Las Palmas, arriving around 12:30 a.m. with a guy pal and one gal. He spent about an hour and a half at the club, drinking vodka and chatting on the patio about his new Roosevelt Hotel nightclub-meets-theater venture, David Arquette Presents: Beacher's Madhouse.

At one point in the night he was spotted talking to not one, not two, but five blondes! One of the ladies even tried kissing him on the lips but was unsuccessful because Arquette pulled away from her.

Arquette left around 2 a.m. with a guy friend.

In other celebrity sightings, Paris Hilton went shopping at Beverly Hills boutique Chagoury Couture, where she picked out a cocktail gown for this weekend's Carousel of Hope Ball benefiting the Children's Diabetes Foundation.

In NYC, Gerard Butler, Leonardo DiCaprio and Lukas Haas enjoyed music spun by DJ Cobra at club Avenue on Monday night.

John Stamos and Johnny Knoxville hit Las Vegas to see funnyman Don Rickles' headline at the Orleans Hotel and Casino. Afterward, all three headed to the Palazzo's Lavo restaurant where they were joined by music legend Quincy Jones.

Also in Sin City was Mickey Rourke—escorted by bodyguards, no less—spotted at Encore's Surrender Nightclub sitting at a VIP table with friends and enjoying electronic music spun by the Eye Candy Twins.

Sandra Bullock spent last week vacationing with baby Louis in the Caribbean. The Oscar winner was spotted at the Viceroy Anguilla hotel.

Kylie Minogue will host amfAR's Inspiration Gala in Los Angeles on Oct. 27 at the Chateau Marmont hotel. The night, cosponsored by Piaget and DSquared, includes a performance by Dita Von Teese.

—Additional reporting by Ashley Fultz

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