Other red carpets are gonna look like amateur hour compared to tonight's all-star assembly.

More than 100 celebrities—and pretty much every network, including E! and right here on E! Online—will join together for the Stand Up to Cancer telethon, an hourlong fundraiser to benefit innovative cancer research.

News anchors Katie Couric, Diane Sawyer and Brian Williams will host the commercial-free affair, which earned a whopping $100 million for its 2008 inaugural airing, and the gravitas-tic pundits will be joined by a who's who of A-list Hollywood. Such as...

George Clooney, Ryan Seacrest, Adam Sandler, Christina Applegate, Cindy Crawford, Eric Stonestreet, who tweeted his challenge today, Gwyneth Paltrow, Jim Parsons, Denzel Washington, Michael C. Hall, Renée Zellweger, Robin Roberts, Seth MacFarlane, Rob Lowe, Vanessa Hudgens, Stevie Wonder, Queen Latifah, Lady Antebellum, Neil Diamond, Green Day, Leona Lewis, Martina McBride and more.

And we're livestreaming the full hour right here, starting at 4:28 p.m. PT/7:28 p.m. ET. Don't miss a minute!

Feeling generous? Text STAND to 40202 to donate $10. To donate any amount, phone in during the telethon or go to www.su2c.org anytime; 100 percent of donations received from the public will go to cancer research.

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