Prepare yourself with the biggest box of tissues you can find because when Grey's Anatomy returns on Sept. 24, everyone will be crying their eyes out.

Jessica Capshaw, the newest series regular (Dr. Arizona Robbins), teases the aftermath of George's departure and how things will be different on the set without T.R. Knight. "Heavy" is the best way to describe this season, as compared with the last five.

Also, with Amy Brenneman's comment on the drama at Grey's, Jessica tells us how she deals with her 17-hour workdays (ahem, Ms. Heigl), especially since she also has a child.

Most importantly, Jessica spills what we all want to hear: Callie (Sara Ramirez) and Arizona's relationship is going to progress this season.

Check out the video above to get the details on why this season premiere will be the best yet, and then hit the comments to discuss your feelings on George's death.


Catch up on all the Grey's Anatomy scoop before its fall return.

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