While introducing the track, Adele explained that although she'd never met Matthew, he—as well as his beloved Friends character Chandler Bing—will always be a part of some of her "favorite" childhood memories.
"One of my friends, Andrew, when I was 12 did the best Chandler impression," she told the crowd. "And he would do it all the time to make us laugh. And if anyone was having a bad day or feeling low, he would just pretend to be Chandler. And I'll remember that character for the rest of my life."
"He was so open with his struggles with addiction and sobriety, which I think is incredibly, incredibly brave," she added. "I just wanna say how much I love what he did for us, especially what he did for me. One of the best comedians...and hopefully now he can rest in peace."
Rachel Murray / Getty Images for Clinique/Screen Media Films / Dayn Nanda / E! News