On Wednesday, April 21, the One Tree Hill alum shared the shocking announcement with her Instagram followers. Jana has also filed for divorce from the 34-year-old athlete.
"As I try to make sense of a reality I never wanted to believe could be possible again, those words have now become a reality," she began her post. "I've fought y'all. I've loved hard. I've forgiven. I've put the work in. I've given everything I have, and now I have nothing else to give. 'It's time.'"
"Please know that I still believe whole heartedly in marriage, love, and rebuilding," the 37-year-old star continued. "I just can't fight any longer. It's time to heal. Thank you for all the love, heart, and support, in many ways you have fought on this journey alongside me, and for that I am grateful."
She signed off, "I'll always encourage you to continue the good fight, but you can't fight it alone."
The former NFL player has yet to publicly comment on their breakup.
As for what may have caused their split? A source tells E! News, "Mike broke her trust yet again. He had so many chances to make this right and she tried and tried, but she was really left with no choice."
They share two kids: Jolie Rae, 5, and Jace Joseph, 2.
Of course, since getting married in 2015, the two have been refreshingly honest about their marital issues, family dynamics and more. Read through their most candid confessions in our gallery below.