Justin Chambers is departing Grey's Anatomy.

ABC confirms to E! News that after 16 seasons on the ABC series, Chambers, who portrays Dr. Alex Karev, is set to make his exit. The 49-year-old actor also confirmed the news himself in a statement on Friday.

"There's no good time to say goodbye to a show and character that's defined so much of my life for the past 15 years," Chambers said in his statement to E! News. "For some time now, however, I have hoped to diversify my acting roles and career choices. And, as I turn 50 and am blessed with my remarkable, supportive wife and five wonderful children, now is that time."

Chambers went on to say, "As I move on from Grey's Anatomy, I want to thank the ABC family, Shonda Rimes, original cast members Ellen Pompeo, Chandra Wilson and James Pickens, and the rest of the amazing cast and crew, both past and present, and, of course, the fans for an extraordinary ride."

The date of Chambers' final episode on Grey's Anatomy has yet to be announced. His character last appeared in a November episode.

Chambers has been a part of the main cast of Grey's Anatomy since its premiere in 2005. So, we think it's safe to say many fans of the beloved series will be sad to read this news today.

Watch E! News weekday mornings at 7 a.m.! And don't miss our 2020 Grammys: E!'s Inside Guide special Wednesday, Jan. 22 at 11 p.m. for a Grammy Awards preview!

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