Philbin gets his first big break as the announcer for ABC's The Joey Bishop Show.
His countless television credits include That Girl, an ABC sitcom also starring Marlo Thomas.
He also appears as a sideline host for the ABC game show, Almost Anything Goes.
He lands his own eponymous talk show in the early '80s, which featured celebrity guests like Zsa Zsa Gabor.
Live! With Regis and Kathie Lee premieres in 1988 and instantly quickly becomes a nationwide hit.
Regis and Kathie Lee's onscreen dynamic captivates viewers at home. They co-host the morning show until 2000, when Kathie Lee announces her exit.
Daughters Jennifer Philbin and Joanna Philbin support their famous father.
Regis lands a guest spot alongside Will Smith on The Fresh Prince of Bel-Air.
Philbin appears on The Tonight Show With Jay Leno.
From 1999 to 2002, Philbin hosts Who Wants to Be a Millionaire?, which becomes a phenomenon across America.
Philbin is pictured here with wife Joy Philbin, who he married in 1970.
After Kathie Lee's departure, Kelly Ripa is chosen as Regis' new Live! co-host.
The duo continues to entertain audiences for years to come.
Shortly after celebrating his and Ripa's 10-year anniversary, Philbin announces his retirement from Live! after 28 years.
Regis dies on July 24 at the age of 88. His family shares in a statement, "We are deeply saddened to share that our beloved Regis Philbin passed away last night of natural causes, one month shy of his 89th birthday."