In 1946, the Hollywood icon starred as the fourth president James Madison's wife in Magnificent Doll.
Chronicling President Franlin D. Roosevelt's struggles with polio, the 2005 TV film Warm Springs displayed the Sex and the City star as FLOTUS.
The Academy Award winner portrayed the famous First Lady in the 1960 biographical drama Sunrise at Campobello, alongside Ralph Bellamy as FDR.
On her role as the wife of George W. Bush in W., the Hunger Games actress said, "I just want to honor her voice, her stillness and her hairstyle."
The first African-American First Lady was portrayed by the Ride Along actress in Southside with You, a romantic drama about the future POTUS and FLOTUS's first date.
In the 1984 CBS biopic miniseries George Washington, which went onto receive six Emmy nominations, the late actress portrayed America's first First Lady.
Greg Kinnear played JFK in the 2011 miniseries The Kennedys with the Dawson's Creek star playing his wife.
The acclaimed actress was awarded with an Emmy for her work as Gerald Ford's wife in the 1987 TV film The Betty Ford Story.
The 12-time Academy Award nominated Lincoln put the Forrest Gump actress as the wife of Daniel Day-Lewis's Abraham Lincoln.
The Emmy-award winning 1991 miniseries, A Woman Named Jackie, was divided into three parts to chronicle the life of the iconic First Lady, with the I Know What You Did Last Summer star playing a young Jackie Onassis.
And the Touched By an Angel star played an adult Mrs. Kennedy.
The 2008 HBO miniseries on the second President of the United States, John Adams, put the Big C actress as the First Lady, opposite Paul Giamatti as the title character.
The Oliver Stone-directed Nixon saw the Crucible actress as the First Lady, for which she received an Oscar nomination, with Anthony Hopkins playing POTUS.
Jackie O.'s motherhood was at the forefront in her portrayal by the Murder on the Orient Express actress in the TV film America's Prince: The John F. Kennedy Jr. Story.
The Exorcist actress starred alongside Banks as W.'s mother.
The Kennedy wife was a supporting character in the 2009 HBO film Grey Gardens, depicting the lives of some of Jackie's eccentric relatives, though the actress still received an Emmy nomination for her First Lady portrayal.
2013's The Butler saw a number of stars bring historic American figures to screen, including Alan Rickman as 40th president Ronald Reagan and the iconic actress as his wife.
The film also saw the Friday Night Lights star as the wife to James Marsden's John F. Kennedy.
The SNL cast member nailed her impression of the current FLOTUS in a number of sketches, down to her Slovenian accent.
Depicting JFK's assassination, Killing Kennedy put the Big Love star as FLOTUS and Rob Lowe as her husband.
Who did it better? The comedian portrays Mrs. Obama to argue with Hillary Clinton (Vanessa Bayer) about who was the better First Lady on Saturday Night Live.
The First Lady was front and center in the 2016 biopic Jackie, with the Star Wars star as the title character, earning her a Best Actress nomination at the Academy Awards.
Though she was playing Hillary, the presidential candidate and not Hillary, the First Lady, the comedian's impersonation on Saturday Night Live is too iconic not to include.