For the show's nine-season run, NPH starred as Barney Stinson—a suave womanizer who loves the finer things in life. There's no doubt about it, this role was, legen...wait for it...dary!
Opposite Ben Affleck and Rosamund Pike, the brilliant comedian took a turn for the sinister in this wildly popular thriller. Spoiler alert: Harris's character unfortunately met a pretty bloody (and frightening) demise.
We're still recovering from Harris' time on the fourth season of American Horror Story. The actor starred as a traveling salesman turned ventriloquist who becomes manipulated by a dummy. Yikes!
In this comedy, Harris teamed up with Seth MacFarlane, Charlize Theron and Amanda Seyfried to take on the wild, wild west.
Harris revived his role as Steve the Monkey in this 2013 sequel to save the world from a group deliciously dangerous living food animals called foodimals.
During the show's inaugural season, Harris made a guest appearance as a former McKinley High School glee club member committed to shutting down the musical crew because of his own personal failures. Not to worry, though, Mr. Schue (Matthew Morrison) sacrifices his own starring role in the local production of Les Misérables for Harris and saves New Directions.
After Smurfette is kidnapped by the evil wizard Gargamel, the little blue forest creatures must team up with their human friend (Harris) to save her.
NPH makes a memorable cameo appearance in this 2011 comedy, appearing as the host of the Muppets Telethon.
Who doesn't want to see NPH as a diabolical singing dolphin named Dr. Blowhole?
Harris and Elmo came together to discuss the word "curly." Now that's a hairstyle we'd like to see more often!
NPH wiped his former, squeaky clean child star persona clear from everyone's minds with this racy 2004 role.
In this 1997 science fiction flick, Harris leads an interstellar battle pinning mankind against a killer specie of insects.
At just 16-years-old, Harris burst into Hollywood as boy genius surgeon Doogie Howser. In 1992, NPH even received his first Golden Globe nomination for the starring role. Talk about a star in the making!