"Done," the Veep star wrote when she completed the cold challenge.
"If you're gonna go in , you gotta go ALLLLLLL in. #ALS," the former Glee star wrote before taking her challenge deeper into the water.
Dressed in scrubs, Jesse Williams, Ellen Pompeo, Jessica Capshaw and more cast members completed the challenge.
Hubby and kids got in on the ALS challenge fun by pouring ice cold water on the former Beverly Hills, 90120 star's head.
"#ALSIceBucketchallenge CC: @3gerardpique @giseleofficial #PopeFrancis @coldplay #ChrisMartin," Shakira wrote when she shared her video on Instagram.
The Bon Jovi frontman shared a YouTube video of himself getting drenched with ice water on Aug. 16 and nominated his band mates to go next.
The Poison rocker underwent the freezing task onstage during a solo show.
The Guardians of the Galaxy star pre-gamed before his challenge.
The pop and country superstar and husband Mike Fisher took the Ice Bucket Challenge to the extreme!
The Arrow hunk stripped down for his challenge ...
The always stylist Scandal star went 2 for 2!
The pop and country superstar shared a video of herself and the model and actress taking on the challenge at a 2014 MTV Video Music Awards rehearsal and it was SO money!
Iron Man himself appeared wet and shirtless when he took on the challenge, administered by his loving, pregnant wife, Susan Downey.
The tech tycoon devised a creative way to complete the Ice Bucket Challenge after accepting Mark Zuckerberg's nomination to partake in the frigid fun.
The media mogul shared her video with BFF Gayle King taking part in the fun and challenged "#StevenSpielberg, #HelenMirren and @DayalManish. In the name of ALS..."
The "Really Don't Care" singer took to her Facebook page to participate in the challenge.
The handsome crooner shared his video on both Instagram and Facebook, where he wrote: "#ALSIceBucketChallenge. Thanks #PatrickDownes & #JessicaKensky for nominating me and The Tennessee Kids. We now nominate The Tonight Show Starring Jimmy Fallon and The Roots..."
The Tonight Show host and his house band happily obliged, along with comedians Rob Riggle and Horatio Sanz.
The Fault in Our Stars actor posted his video to Instagram and wrote, "This is for a good cause, #als aka #lougehrigsdisease research! I may scream like a girl at the end, but I donated like a man!!! (Lol) I gave 500$ today! What will you give??"
The Walk of Shame star took to her website to show off her video and challenge "Seth Rogen, Jesse Tyler Ferguson and Nathan Fillion to do it next."
The rapper joined in on the challenge in his latest YouTube installment of "Weezey Wednesdays."
The brunette beauty wrote, "I nominate my costars from @yournotyoumovie: @joshduhamel & @HilarySwank," when she posted her video to Instagram.
The Voice crew accepted the challenge together.
The pop singer said "I accepted the #alsicebucketchallenge!," and nominated her sisters and friends to participate when she posted her video.