Grey's Anatomy, Ellen Pompeo, Patrick Dempsey

ABC

Grey's Anatomy has enough drama to fill a lifetime prescription, but there's so much more to the show than heartbreak and medical emergencies.

For 15 seasons, Grey's has centered around surgeon Meredith Grey (played by Ellen Pompeo) and her co-workers at Grey-Sloan Memorial Hospital. There's a plethora of love, sex, drama, near-death experiences, death and, well, more drama.

Since beginning its landmark 15th season, it has officially become the longest-running primetime drama on ABC. It's a central part of creator Shonda Rhimes' "Shondaland" show marathon. Having been around the primetime block a few times, fellow famous faces have made brief appearances throughout the show's tenure. Big names have come and gone from the show, including Patrick Dempsey as Dr. Derek Shepherd (McDreamy) aka Meredith's love interest before he was killed off in season 11. Plus, there's Sandra Oh as Dr. Christina Yang and, new to the show, Chris Carmack of The O.C. fame.

As season 15 makes its way through the season, take a look back at some of the best celebrity cameos on the show, as seen below.

Grey's Anatomy, Cameos, Millie Bobby Brown

ABC

Faye Dunaway, Greys Anatomy

Ron Tom/ABC via Getty Images

Mandy Moore, Grey's Anatomy

ABC

Demi Lovato, Greys Anatomy Guest Stars, Season 6

Mitch Haddad/ABC via Getty Images

Grey's Anatomy, Cameos, Zach Gilford

ABC

Grey's Anatomy, Cameos, Leslie Grossman

ABC

Isaiah Washington, Kyle Chandler, Greys Anatomy

ABC

Sarah Paulson, Greys Anatomy

ABC

Grey's Anatomy, Cameos, Elisabeth Moss

ABC

Grey's Anatomy, Cameos, Jesse Plemons

ABC

Grey's Anatomy, Cameos, Matt Lanter

ABC

Scott Foley, Greys Anatomy

ABC/ADAM TAYLOR

Grey's Anatomy, Cameos, Christina Ricci

ABC

Greys Anatomy Cameo

Eric McCandless/ABC via Getty Images

Josh Radnor, Ellen Pompeo, Grey's Anatomy

Charles Sykes/NBC; ABC

The show has aired over 320 episodes, which allowed for ample cameo opportunities.

Which celebrity will make an appearance next? Only time—and dramatic medical emergencies—will tell.

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