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Emma Stone, Jonah Hill, Sally Field, Justin Theroux...No, this is not the cast of the latest A-list ensemble rom-com, it's the cast of Netflix's new miniseries Maniac created by Patrick Somerville and directed by Cary Joji Fukunaga.

And no, this isn't a Superbad sequel. The series follows Hill's Owen and Stone's Annie during a mysterious drug trial. But it's not just a normal drug trial. No, this is a TV show, it's going to get weird.

"It's not therapy, it's science," Theroux's Dr. James K. Mantleray says in the trailer. And yes, it's a trippy trailer.

Maniac, Emma Stone, Jonah Hill

Michele K. Short / Netflix

"Pain can be destroyed. The mind can be solved," he says.

Stone's character sums up the show perfectly: "This is some multi-reality brain magic s—t," she says.The trailer features the two characters hopping through realities…of their brains? There's a Middle Earth-esque one, a very suburban setting (mullets are involved) and some very 1950s-looking scenes.

It's a trippy love story for the ages. The cast of Maniac also includes Sonoya Mizuno, Julia Garner, Jemima Kirke, Gabriel Byrne and Billy Magnussen.

Maniac debuts globally September 21 on Netflix.

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