George Clooney, Amal Alamuddin

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George Clooney and Amal Alamuddin's wedding weekend had its share of A-list guests.

From John Krasinski and Cindy Crawford to Bono and Anna Wintour, several recognizable faces made the trip to Venice, Italy to witness the couple say "I Do."

But despite a star-studded affair, two of Clooney's closest friends were nowhere to be found. Where in the world were Brad Pitt and Ben Affleck?

Turns out they had to work!

According to a source, Pitt and wife, Angelina Jolie, were participating in international movie shoots that required long hours in order to keep production costs down. As a result, missing three days for the festivities wasn't possible.

Angelina Jolie, Brad Pitt, George Clooney

Jeff Kravitz/FilmMagic for Variety Magazine

"Both of them have worked on movies where this sort of issue has come up and so has George so of course he'll completely understand and not feel snubbed by them or anything like that," a source told E! News. "This movie is such a great project for Brad and Angie and they have to stay focused and in the zone."

In comparison, Affleck was hard at work in New York City promoting the release of his new movie, Gone Girl. While walking the red carpet at the film's premiere, the actor couldn't help but share his well wishes for the couple.

"You know, some of us have to work," Affleck joked to E! News. "But yes, I congratulate him. It's very exciting."

To nobody's surprise, Clooney's close friends are head over heels in love with Alamuddin. In addition to being impressed with her career as a human rights lawyer, friends also believe Clooney has finally met the love of his life.

George Clooney, Ben Affleck

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"Brad and Angie are so excited for George and Amal," a source told E! News. "They are getting a staffer to send [them] a case of their own Chateau Miraval wine so they can toast the wedding once they get home."

The source added, "Brad knows that George and Amal will be talking about the wedding and remembering it all excitedly non-stop for weeks and weeks—just like they have been doing as well."

Love is certainly in the Hollywood air! Congrats once again to the happy couple!

—Reporting by Jen Paul

For more on George and Amal's wedding, watch E! News tonight at 7:00 p.m. and 11:00 p.m.  

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