Who's the boss of the bathroom? The Old Spice Guy!

Clad in only a towel but slathered in handsome, viral video sensation Isaiah Mustafah filmed nearly 100 personalized YouTube responses this week to his Twitter fans. Celebritweeters receiving messages from the spicy ladies man include Ashton Kutcher (with "1.2 kabillion followers") and wife Demi Moore, Ellen DeGeneres and Ryan Seacrest. Alyssa Milano was honored by four videos.

Then Buzzkill Milano had to respond with her own wet towel of a video. Normally we'd be thrilled to see the gorgeous Charmed star undressed, but her politically charged rejoinder is boring and gauche—everything the Old Spice Guy is not.

See more of the suave spokesman's messages to the stars after the jump...

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You never know what might happen if you follow E! Online on Twitter!

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