It seems like it would be impossible to offend Amy Schumer, but if you call her Trainwreck character "skanky," it will absolutely set her off.
That's what Australia's KIIS 101.1's Matt Tilley did, and he is probably really regretting that decision since Schumer absolutely shut him down upon hearing his judgment of her role. Prior to his name-calling, the interview was actually going pretty well, but he took a wrong turn and it only got more awkward from there.
"Do you have the word skanky in America?" Tilley asked, which caused an unimpressed-looking Schumer to joke that he was thinking about his mother.
"Come on, that's the character in the movie. I'm not trying to offend you," he said.
But the Inside Amy Schumer star wasn't having it. "Whatever you are trying to do, you are [doing]. That's a rude question."