It's the end of an era: Justin Chambers is checking out of Grey's Anatomy.

The 49-year-old actor and ABC announced on Friday that he is leaving the medical drama after playing Dr. Alex Karev on the show since it debuted 16 seasons ago.

"There's no good time to say goodbye to a show and character that's defined so much of my life for the past 15 years," Chambers said in a statement. "For some time now, however, I have hoped to diversify my acting roles and career choices. And, as I turn 50 and am blessed with my remarkable, supportive wife and five wonderful children, now is that time." 

Chambers has announced no new acting projects in the works.

He joins other notable original cast members who have departed the series: Katherine Heigl, who played Dr. Izzie Stevens and left after six seasons, Patrick Dempsey, who played Dr. Derek "McDreamy" Shepherd for the first 11 seasons, and Sandra Oh, who played Dr. Cristina Yang and left after 10 seasons. Nowadays, she is known for her role on Killing Eve, for which she won a Golden Globe last year.

Other Grey's Anatomy alumni include T. R. Knight, Eric DaneSara Remirez and Chyler Leigh.

Check out what the departed doctors of Grey's Anatomy have been doing in recent years.

Justin Chambers, Greys Anatomy

ABC

Isaiah Washington, Grey's Anatomy

Craig Sjodin/ABC

Edward Herrmann, Grey's Anatomy

ABC

Kali Rocha, Grey's Anatomy

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T.R. Knight, Grey's Anatomy

Craig Sjodin/ABC via Getty Images

Brooke Smith, Grey's Anatomy

Randy Holmes/ABC via Getty Images

Brandon Scott, Grey's Anatomy

Karen Neal/ABC via Getty Images

Katherine Heigl, Grey's Anatomy

Frank Ockenfels/ABC

Molly Kidder, Grey's Anatomy

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Joseph Williamson, Grey's Anatomy

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Mark Saul, Grey's Anatomy

Michael Desmond/ABC via Getty Images

Sarah Utterback, Grey's Anatomy

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Gloria Garayua, Grey's Anatomy

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Nora Zehetner, Grey's Anatomy

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Robert Baker, Grey's Anatomy

Eric McCandless/ABC via Getty Images

Rachael Taylor, Grey's Anatomy

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Kate Walsh, Grey's Anatomy

Karen Neal/ABC via Getty Images

Chyler Leigh, Grey's Anatomy

Adam Larkey/ABC

Eric Dane, Grey's Anatomy

Randy Holmes/ABC

Charles Michael Davis, Grey's Anatomy

Eric McCandless/ABC via Getty Images

Tina Majorino, Grey's Anatomy

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Geena Davis, Grey's Anatomy

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Sandra Oh, Grey's Anatomy

Ron Tom/ABC

Gaius Charles, Grey's Anatomy

Richard Cartwright/ABC

Patrick Dempsey, Grey's Anatomy

ABCRandy Holmes/ABC via Getty Images

Tessa Ferrer, Grey's Anatomy

Richard Cartwright/ABC

Sara Ramirez, Grey's Anatomy

Eric McCandless/ABC via Getty Images

Samantha Sloyan, Grey's Anatomy

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Marika Domincyzk, Grey's Anatomy

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Jerrika Hinton, Grey's Anatomy

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Martin Henderson, Grey's Anatomy

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Jeanine Mason, Grey's Anatomy

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Sarah Drew, Grey's Anatomy

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Jessica Capshaw, Grey's Anatomy

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Rushi Kota, Grey's Anatomy

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