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Want to know the secret to John Stamos and Rob Lowe's eternal youth? No, it's not virgin unicorn blood, although that sounds totally plausible considering both of these babes are looking better than ever in their early 50s.

E! News caught up with the stars of Fox's brand-new Tuesday night comedy block of Grandfathered and The Grinder, premiering tonight at 8 p.m., to discuss what keeps them looking so handsome and useful.

"I'm lucky. My parents did well; they looked good," Stamos tells E! News at the Paleyfest preview for both shows in Beverly Hills. "But I'm telling you, one day I'm not going to look so good, so I'm going to prep people for that."

Lowe, on the other hand, has a tried and true method that you can actually purchase: his skincare line, Profile for Men.

Rob Lowe, John Stamos

Frank Micelotta/FOX

"You can get it at Nordstrom," he shares. "I've spent the last six years developing it, and it's what I've been using forever."

Not only does Lowe use the brand, so does his costar, the babyfaced Fred Savage. "He has a skincare line that I've asked him for," he confesses. Wait—can't you tell that he's a Profile customer?

"When I walked past, you should've been like, 'Oh my god, that's a Profile for Men user,'" he teases. "Don't I look years younger?"

Want to look years younger? You should probably buy Profile too. Adds Savage, "Yeah, you'll look like me!"

Grandfathered airs at 8 p.m. and The Grinder follows at 8:30 p.m. Tuesday nights on Fox.