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How I Met Your Mother

Ron P. Jaffe/Fox

Let's get real, is there anything Neil Patrick Harris can't do? 

The actor has made us laugh till we cry on How I Met Your Mother, hide as far as possible under the covers during his time on American Horror Story and even taught some pretty valuable life lessons on Sesame Street. And who can forget his time as the child prodigy medical doctor on Doogie Howser, M.D.? Handling the woes of teenage romantics and open heart surgery was all in a day's work for Harris.

Now the Emmy and Tony award-winner is taking on an entirely new project, hosting and starring in Best Time Ever with Neil Patrick Harris. The live variety show will include mind boggling stunts, skits, pranks and musical numbers all with that signature NPH touch. 

You can't miss Best Time Ever when it premieres Tuesday, Sept. 15 at 10 p.m., but until then catch up with Harris by looking back at his most memorable moments in entertainment. What is your favorite Harris role? Sound off in the comments below! 

(E! and NBC are both part of the NBCUniversal family.)