From Material Girl to Dita to Her Madgesty and every different persona in between, Madonna has had more nicknames than most artists have had albums.
But as we reflect back on her still buzzing career, the icon simply looks fab here, reflected in the top of her limo as she and hubby Guy Ritchie leave her B-day party Volstead Club in London. Rock on, girly!
Which gets us to thinking, who else is Fabulous at 50? Check out our gallery of high-mileage hotties here.