ABC's fall schedule is no laughing matter.

The Alphabet net unveiled its fall prime-time lineup Tuesday, with 11 new shows—the most of any of the big networks—and a slew of established stars aligning to make the cut. Seven of the newbies are dramas, including Grey's Anatomy spinoff Private Practice, the most expected pickup in the history of upfronts, the Michael Vartan-led CEO drama Big Shots and Peter Krause's Dirty Sexy Money.

Also on the new slate are four would-be comedies, a genre where success has eluded ABC in recent years. The most buzzed-about is Cavemen, the Neanderthals-in-suburbia sitcom based on the commercials for Geico Insurance—though presumably with more of an emphasis on subversive digs at the current state of race relations and less about rising car insurance costs.

Still, the biggest and yet least newsworthy order by ABC was Private Practice, which was ordained as the network's next big thing since news of its production was leaked earlier this year. About 21 million viewers tuned in for an expanded two-hour Grey's Anatomy episode that served as Private Practice's launching pad, in which Kate Walsh's Addison Montgomery gave up her gig at Seattle Grace Hospital and headed for the greener, sunnier and more holistic pastures of Los Angeles' Oceanside Wellness Clinic.

The show is scheduled to run Wednesdays at 9 p.m., joined by two new dramatic efforts, Pushing Daisies and Dirty Sexy Money. (Lost, which has been airing in the 10 p.m. slot on hump day, won't return until January, at which point ABC president Steve McPherson said it will likely make the jump to an earlier time slot.)

Pushing Daisies has the proven pedigree of Bryan Fuller (a cocreator of NBC's Heroes) and filmmaker Barry Sonnenfeld, and is set to fill the gaping "forensic fairy tale" hole in the network's prime-time schedule. The series, starring Lee Pace, Anna Friel, Chi McBride, Swoosie Kurtz and Kristin Chenoweth, follows a man who realizes he can bring things—fruit, former high school sweethearts, the usual—back from the dead. However, there's a catch. For instance, if he ever touches his former love, she will return to the dead for good.

The show is already garnering heavy buzz and has been chosen by several critics as the breakout show of the fall season.

Dirty Sexy Money, meanwhile, stars Peter Krause and Donald Sutherland, and centers on a lawyer dealing with his father's suspicious death while ascending to his late daddy's job as the private attorney of the über-rich and über-secretive Darling family.

Another newcomer, Big Shots, tells the story of four male CEOs and the women who tolerate them. The soapy series stars Michael Vartan, Dylan McDermott, Christopher Titus, Joshua Malina and Nia Long.

And the familiar faces aren't stopping there.

Vartan's former Alias compadre Victor Garber is also making his return to prime time in Eli Stone, a legal drama from Alias and Brother & Sisters director Ken Olin and prolific Brothers & Sisters exec producer Greg Berlanti. Eli Stone, which stars Jonny Lee Miller as the titular San Francisco attorney who is diagnosed with a brain aneurysm and begins to suspect that instead of a medical problem he has been given a higher calling.

Another TV vet forging a comeback on ABC's airwaves is Christina Applegate, who will star in one of the network's few comedies, Sam I Am, about a coma victim who wakes to find that she was not particularly liked before her accident. Jean Smart, Gilmore Girls' Melissa McCarthy and Jennifer Esposito costar.

Arrested Development's Judy Greer stars in the sitcom Miss/Guided, which follows a onetime gawky teen who returns to her old high school to serve as a guidance counselor. Ashton Kutcher is executive producer, while writers from The Office and Scrubs pen the show.

Rounding out the four ordered comedies is Carpoolers, which, as the title suggests, focuses on  four co-commuting men from very different backgrounds. Faith Ford and Jerry O'Connell star.

Meanwhile, while NBC announced Monday that the Law & Order franchise would remain afloat for yet another year, ABC has opted to employ one of the show's more famous alums. Angie Harmon is among the stars of Women's Murder Club, based on the James Patterson book of the same name, chronicling a detective, a district attorney, a medical examiner and a reporter, who all work together to solve San Francisco crimes.

The last of ABC's new dramas, Cashmere Mafia, is the long anticipated project from Sex and the City exec producer Darren Star. The girl-powered series follows four ambitious and sexy best friends—sound familiar?—as they juggle their glamorous personal and private lives. Lucy Liu leads the cast. However, the series, along with returning shows Notes from the Underbelly and October Road, has been left off the preliminary schedule.

All three series are slated to premiere on Monday nights after Dancing with the Stars and The Bachelor wrap up their shortened fall cycles.

The final new show ordered by ABC is one of the two previously announced efforts from Oprah Winfrey, Oprah's Big Give.

The do-good series, the first prime-time offering from Harpo Productions, will take contestants to eight different cities with the task of giving out money in not only the most creative way, but in a way that makes the most difference. At the end of the series, one person will be deemed the Biggest Giver. Along the way, several friends of Oprah will likely make appearances on the benevolent tour.

Meanwhile, the axe fell on George Lopez, What About Brian, Knights of Prosperity, In Case of Emergency and Six Degrees.

Despite having stronger ratings than some of the reupped series, McPherson said the nixed shows, especially George Lopez, were simply no longer cost-effective. It's an opinion not everyone agrees with, including Lopez, who told the Los Angeles Times he blamed his cancellation on the fact that his show was produced by Warner Bros., not ABC.

"I get kicked out for a...caveman and shows that I outperformed because I'm not owned by [ABC]? So a...Chicano can't be on TV but a...caveman can?

"You know when you get in this that shows do not last forever, but this was an important show and to go unceremoniously like this hurts."

ABC may just have one last-minute reprieve up its sleeve, however. According to Jim, which was left off the upfronts schedule, may still return as a midseason replacement.

Here's a rundown of ABC's 2007-08 schedule, with new shows in bold.

Monday: Dancing with the Stars, Sam I Am, The Bachelor

Tuesday: Cavemen, Carpoolers, Dancing with the Stars: Results Show, Boston Legal

Wednesday: Pushing Daisies, Private Practice, Dirty Sexy Money

Thursday: Ugly Betty, Grey's Anatomy, Big Shots

Friday: Men in Trees, Women's Murder Club, 20/20

Saturday: Saturday Night College Football

Sunday: America's Funniest Home Videos, Extreme Makeover: Home Edition, Desperate Housewives, Brothers & Sisters

For the latest from the network upfronts, check out TV columnist Kristin Veitch's dispatches in Watch with Kristin.