- Best Traditional R&B Vocal Performance
- "Christmas Time Is Here," Anita Baker
- "God Bless the Child," George Benson and Al Jarreau Featuring Jill Scott
- "I Found My Everything," Mary J. Blige Featuring Raphael Saadiq
- "You Are So Beautiful," Sam Moore Featuring Billy Preston, Zucchero, Eric Clapton and Robert Randolph
- "How Sweet It Is (to Be Loved by You)," the Temptations
- Best Urban/Alternative Performance
- "Crazy," Gnarls Barkley
- "That Heat," Sergio Mendes Featuring Erykah Badu and Will.I.Am
- "Mas Que Nada," Sergio Mendes Featuring Black Eyed Peas
- "Idlewild Blue (Don't Chu Worry 'Bout Me)," Outkast
- "3121," Prince
- Best R&B Album
- The Breakthrough, Mary J. Blige
- Unpredictable, Jamie Foxx
- Testimony: Vol. 1, Life & Relationship, India.Arie
- 3121, Prince
- Coming Home, Lionel Richie
- Best Contemporary R&B Album
- B'Day, Beyoncé
- Chris Brown, Chris Brown
- 20 Y.O., Janet Jackson
- Kelis Was Here, Kelis
- In My Own Words, Ne-Yo
- Best Rap Solo Performance
- "Touch It," Busta Rhymes
- "We Run This," Missy Elliott
- "Kick, Push," Lupe Fiasco
- "Undeniable," Mos Def
- "What You Know," T.I.
- Best Rap Performance by a Duo or Group
- "Ridin," Chamillionaire Featuring Krayzie Bone
- "Georgia," Ludacris and Field Mob (Featuring Jamie Foxx)
- "Grillz," Nelly Featuring Paul Wall, Ali and Gipp
- "Mighty 'O'," Outkast
- "Don't Feel Right," the Roots
- Best Rap/Sung Collaboration
- "Smack That," Akon Featuring Eminem
- Déjà vu," Beyoncé Featuring Jay-Z
- "Shake That," Eminem Featuring Nate Dogg
- "Unpredictable," Jamie Foxx Featuring Ludacris
- "My Love," Justin Timberlake Featuring T.I.
- Best Rap Song
- " It's Goin' Down," Yung Joc (Chadron Moore and Jasiel Robinson, songwriters)
- "Kick, Push," Lupe Fiasco (Wasalu Muhammad Jaco, songwriter)
- "Money Maker," Ludacris featuring Pharrell (Christopher Bridges and Pharrell Williams, songwriters)
- "Ridin," Chamillionaire featuring Krayzie Bone (Anthony Henderson, J. Salinas, O. Salinas and Hakeem Seriki, songwriters)
- "What You Know," T.I. (A. Davis and Clifford Harris, songwriters; Donny Hathaway, Leroy Hutson and Curtis Mayfield, songwriters)
- Best Rap Album
- Lupe Fiasco's Food & Liquor, Lupe Fiasco
- Release Therapy, Ludacris
- In My Mind, Pharrell
- Game Theory, The Roots
- King, T.I.
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