- Best Pop Vocal Album
- Back to Basics, Christina Aguilera
- Back to Bedlam, James Blunt
- The River in Reverse, Elvis Costello and Allen Toussaint
- Continuum, John Mayer
- FutureSex/LoveSounds, Justin Timberlake
- Best Solo Rock Vocal Performance
- "Nausea," Beck
- "Someday Baby," Bob Dylan
- "Route 66," John Mayer
- "Saving Grace," Tom Petty
- "Lookin' for a Leader," Neil Young
- Best Rock Performance by a Duo or Group with Vocal
- "Talk," Coldplay
- "How to Save a Life," the Fray
- "Steady, as She Goes," the Raconteurs
- "Dani California," Red Hot Chili Peppers
- "The Saints Are Coming," U2 and Green Day
- Best Rock Album
- Try!, John Mayer Trio
- Highway Companion, Tom Petty
- Broken Boy Soldiers, the Raconteurs
- Stadium Arcadium, Red Hot Chili Peppers
- Living with War, Neil Young
- Best Alternative Music Album
- Whatever People Say I Am, That's What I'm Not, Arctic Monkeys
- At War with the Mystics, the Flaming Lips
- St. Elsewhere, Gnarls Barkley
- Show Your Bones, Yeah Yeah Yeahs
- The Eraser, Thom Yorke
- Best Female R&B Vocal Performance
- "Ring the Alarm," Beyoncé
- "Be Without You," Mary J. Blige
- "Don't Forget About Us, " Mariah Carey
- "Day Dreaming, " Natalie Cole
- "I Am Not My Hair," India.Arie
- Best Male R&B Vocal Performance
- "Heaven," John Legend
- "So Sick," Ne-Yo
- "Black Sweat," Prince
- "I Call It Love," Lionel Richie
- "Got You Home," Luther Vandross
- Best R&B Performance by a Duo or Group with Vocals
- "Breezin'," George Benson and Al Jarreau
- "Love Changes," Jamie Foxx Featuring Mary J. Blige
- "Everyday (Family Reunion)," Chaka Khan, Gerald Levert, Yolanda Adams and Carl Thomas
- "Family Affair," (Sly and the Family Stone), John Legend, Joss Stone with Van Hunt
- "Beautiful, Loved and Blessed," Prince and Támar
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