Why He Will Be Nominated: Cryer has been a staple in the Supporting Actor category, but with Charlie Sheen out of the picture, it's time for him to be bumped to a lead nomination for taking over the show after Sheen crashed and burned left Two and a Half Men.
Why He Won't: Voters might not see him as leading man material, and all the drama from Two and a Half Men the past year might hurt his chances at a nod.