Mark "McSteamy" Sloan finally dies after his plane-crash coma. Oh, and then—oops!—Arizona gets her leg amputed.
Lexie dies after the shocking plane crash.
Meredith and Derek become parents to adopted daughter Zola.
Cristina gets stabbed by an icicle.
Meredith watches as a gunman shoots Derek.
While getting frisky in an on-call room with Lexie, Mark breaks his penis.
A pregnant Callie goes head first through the windshield. Singing ensues.
Derek's wife, Addison, shows up in Seattle.
Cristina is left at the alter by Dr. Burke.
Derek and Meredith make it official and get married on a Post-It.
Meredith drowns in the icy Seattle water.
Grey's guest star Kyle Chandler blows up.
Meredith realizes that George is bus crash victim John Doe.
Izzie's fiancé, Denny, dies after a heart transplant.
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