In what can only be described as a "Downey-esque" bit of business, the actor suggested that the key to a Best Actress nomination was spending some sexy time with him.
In possibly the sweetest moment of the evening, Cuoco literally jumped for joy when she read the name of her Big Bang costar.
The two talented teens introduced—what else?—the best animated film award.
Always a delight, the actress' mere presence rendered Paul Giamatti into a delighted, babbling fool. And who could blame him?
Even award shows need eye candy, and we are grateful.
So funny. The Glee actress praised the writer who came up with the Sue Sylvester character, while at the same time showing off her own sharp, creative mind with some hilarious quips.
In maybe the funniest bit of the night, the two cuties goofed on fake-sounding award show intros...with one of their own.
The actor gave a wonderfully funny speech that was totally unexpected from such a serious actor.
The award-winning Glee cutie offered a heartfelt speech on behalf of his show and the kids who are moved by it.
Dude! Last year's big winner was on hand to bestow an award on Natalie Portman, man.
Who doesn't love this guy? Attentive during the show and gracious and funny when winning, the King's Speech actor is the odds-on favorite to win an Oscar, too.
The Inception dreamboat offered an introduction to the film.
In a surprise appearance, the actor came out to announce the final award with a joking reference to his recent bout with cancer, "There's just gotta be an easier way to get a standing ovation."
In a polarizing performance, the comic roasted some of Hollywood's biggest stars, and pushed the boundaries of good taste.
With her exuberant shoutouts to her mother, costars and Fighter director David O. Russell, the actress was a joy to see.
These two seemed to be having some sly fun with the whole proceedings with some exaggerated enunciations and a tone of mock-gravity.
The acting legend picked up a trophy for playing Dr. Jack Kevorkian.
Despite not being up for any awards, the actress still found herself up on the stage to introduce The Tourist.
In a surprise win, the Sons of Anarchy actress picked up a trophy for her gritty performance of a motorcycle gang leader's iron-willed wife.
Despite being introduced as "Ashton Kutcher's father," the veteran actor displayed unflappable cool.
The actor gave a jokey introduction to Cecil B. DeMille award winner Robert De Niro, claiming to have not been familiar with her work.
Always unexpected as an actor, he totally surprised everyone with a stand-up routine in lieu of a serious speech. Funny, but kind of scary, too.
The brilliant writer won for his Social Network script, as well as celebrated all the smart, successful women in the room.
On a very big night for his film, the Social Network director delivered a terrific speech, too.
Next gallery: 2011 Golden Globes: Fashion Police