The Hollywood veteran plays a former navy officer turned big-time criminal, who after surrendering to the FBI, eludes persecution by turning in other criminals.
A young Spader starred alongside Molly Ringwald, Jon Cryer and Andrew McCarthy in this 1986 coming-of-age classic.
Is that you, James? The actor said playing the Marvel villain was, "indescribable because the technology for all this performance capture stuff and how they shoot it has been revolutionary with every subsequent film."
For four years, Spader starred as ruthless lawyer Alan Shore in the popular TV series. The actor won three Emmys for his portrayal in Boston Legal and The Practice, making him one of only few actors to win an Emmy award while playing the same character in two different series.
In this 2012 historical drama, Spader plays W.N. Bilbo, one of the political operatives hired by President Abraham Lincoln to do behind-the-scenes dirty work preceding the passing of the Thirteenth Amendment.
To Office fans, James is simply Robert California—the wacky, sex-obsessed CEO of Dunder Mifflin.
Widely considered his breakout role, Spader stars as a voyeur who becomes intricately involved in the lives of a married couple.
Spader makes a guest appearance as George's old friend Jason "Stanky" Hanky. Years earlier, Hanky refused to let George borrow a sweater out of fear he'd stretch it out, and George just can't let it go.
In this family friendly flick, the actor puts on his bad-guy cap to steal a wish-granting rock from a few unsuspecting kids.
Maggie Gyllenhaal stars alongside Spader as his office secretary turned submissive sex partner in this pre-Fifty Shades of Grey BDSM flick.
The 1996 film follows Spader as a car crash fetishist.
There's no dust in her Dustbuster! After the death of his wife, Spader's character finds solace in the arms of a waitress played by Susan Sarandon.
Tommy Lee Jones and Hilary Swank also appear in this star-studded period drama set in the 1850s.
Spader finds himself smack dab in the middle of a legal battle between two half-sisters fighting over their ailing father in this satirical medical drama.
Trouble ensues when Andrew McCarthy's Clay returns home from college to find his friend Julian (Robert Downey Jr.) owes a drug dealer (cue Spader) $50,000.
Spader and co-star Kurt Russell unlock the code to an interstellar portal to ancient Egypt in this 1994 thriller.
This politically-charged drama threatens to divide Tim (Spader) and his college roommate Peter (John Cusack).
This 1990 drama follows Spader on his mission to persuade Rob Lowe to break free from his cookie-cutter image and lead a drug-fueled crime spree that ends badly.
Spader stars as the larger than life vice president of a department store chain that houses a mannequin (Kim Cattrall) with the ability to come to life.
The actor plays a hitchhiking con man at the center of a high-stakes poker game.
PHOTOS: The Blacklist: Raymond Reddington's Best Lines