Oprah Winfrey is having a serious moment right now. 

The world-famous television personality and business mogul is InStyle magazine's March 2018 cover star, which was announced Thursday. Wearing an embroidered Gucci jacket with "LOVED" written across the back, Oprah looks over her shoulder and flashes a signature smile. 

Oprah's latest glossy cover comes weeks after a speech she made at the 2018 Golden Globes had many calling for a 2020 presidential run. And while BFF Gayle King described the 63-year-old as "intrigued" by the idea of a shot at the White House, Oprah has kept mum on any potential aspirations—until now.

Oprah Winfrey, InStyle

Phil Poynter/InStyle

"I've always felt very secure and confident with myself in knowing what I could do and what I could not. And so it's not something that interests me," she says. "I don't have the DNA for it."

Unlike President Donald Trump, Winfrey doesn't often use social media to discuss political matters. "I try not to lean into the hysteria. I've heard a lot of Twitter chatter where people have said, 'Where are you? You should be speaking up on these things!' But it makes no sense to speak when you cannot be heard," the star of A Wrinkle in Time tells the magazine. "One hundred and forty characters—that is not how you want to make your mark in the world."

Such criticism might have bothered Winfrey in the past—but not today. Now that she's in her 60s, Winfrey isn't fazed by what her haters say. "You take no s--t. None. Not a bit. In your 40s you want to say you take no shit, but you still do. In your 60s you take none," she says. "There's both a quickening and a calming—there's a sense that you don't have as much time on earth as you once did...People coming with anything less than what is the truth or authentic? Don't even try."

Of course, Winfrey has thought a lot about current political and cultural climate. "Everything that's happened has brought us to this point in time. We've been working our way through a lot of repressed pain, anger, shame, and disappointment," she says. "And we weren't honoring our own voices. Now we're here, and it took Harvey Weinstein to burst that door wide open. But Harvey [Weinstein] wasn't the first one. It was Bill Cosby before him, and Bill O'Reilly before him. It's just fascinating to me because I always try to look at things from thousands of feet above…" As more people come forward about sexism and sexual assault, she says, "It has seared into the consciousness a level of awareness that was not there before. That's the most important thing to me. When Reese Witherspoon can tell her story at the same time as a farm worker in Iowa or a factory worked in Alabama, it says to a person, 'Oh well, I've been putting up with that asshole supervisor for all these years. Maybe it's time for me to do something too.'"

Pick up the latest issue of InStyle on newsstands Feb. 9. 

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