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Charlie Sheen, Hugh Laurie, Kyra Sedgwick, Mary- Louise Parker

CBS; FOX; TNT; Monty Brinton/ Showtime

Yeah, HBO's John Adams dominated noms for the 60th Annual Primetime Emmys, with 23 of 'em. So that'll win. But which shows that you actually watch will clean up next Sunday? Can James Spader house Hugh Laurie? Is Steve Carell more of a man than Charlie Sheen? Will Tina Fey rock Mary-Louise Parker? Could these puns be worse?

Cast your vote in the only official, definite E! Online Readers Predictions poll! (And check back later this week for prediction's from our own Kristin Dos Santos.)

2008 Emmy Predix: The Big Ones
Outstanding Drama Series
6.5
3.4
12.2
27.6
34.1
16.1
Outstanding Comedy Series
2.5
7.8
26.0
41.3
22.4
Outstanding Lead Actor in a Drama Series
11.9
2.4
24.6
45.1
2.3
13.8
Outstanding Lead Actress in a Drama Series
34.7
18.5
17.3
20.9
8.5
Outstanding Lead Actor in a Comedy Series
9.2
28.5
10.6
33.3
18.3
Outstanding Lead Actress in a Comedy Series
9.2
21.7
28.9
17.1
23.0