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Jennifer Lopez made an epic debut in Las Vegas on Wednesday night.

The 46-year-old began her residency with a sold-out show at The Axis at Planet Hollywood Resort & Casino with tons of surprise guests like Ne-Yo, Pitbull and Ja Rule.

Plus stars like Justin Bieber, Ryan Seacrest, Derek Hough, Rosie Huntington-Whiteley and many more celebs were in attendance to see Jennifer dominate the stage, which she definitely did!

Casper Smart, Jennifer's boyfriend, was also in attendance watching her perform!

Want to find out who else was at the show?

Watch the E! News video to get more scoop on J.Lo's opening night in Las Vegas!