She and wife Portia de Rossi, spoke to E! News at the 2015 GLAAD Media Awards in Beverly Hills, California on Saturday.
Dolce & Gabbana founders Domenico Dolce and Stefano Gabbana had made their remarks to an Italian magazine earlier this month, expressing their disapproval of "synthetic children" conceived via artificial insemination and in vitro fertilization, the only viable method of getting pregnant for both same-sex and heterosexual pairs.
"It's not even worth commenting on because they're, you know, ignorant," DeGeneres told E! News.
The 57-year-old talk show host added she will never wear Dolce & Gabbana clothes "ever, ever again."
Dolce and Gabbana's comments had spurred John, who shares two sons with his husband, to call for a boycott of their luxury fashion label Dolce & Gabbana and several celebs soon followed the singer-songwriter's lead. Dolce and Gabbana later clarified their remarks, saying they did not mean to judge other people's choices.
"The only thing you can say is that, you know, we're all entitled to free speech," de Rossi, 42, told E! News. "However, I just don't understand who they are. I don't understand why they would want to say that."
Zoe Saldana, who attended the 2015 GLAAD Media Awards with husband Marco Perego, with whom she shares twin sons, disagrees with the couple's stance. She told E! News it would be "the stupidest thing" to boycott Dolce & Gabbana, adding that she is "certainly not going to be refuting when they are adopting synthetic children, however they wanted to say it."
DeGeneres and de Rossi, who celebrated their 10th wedding anniversary in December, have no children and had last year debunked tabloid reports that claimed the two were trying to start a family.