And they saw 12 Years a Slave steal the show.
The slave drama won big, taking home five awards, including best feature, best director for Steve McQueen, best supporting actress for Nyong'o and best cinematography…and it wasn't the only big winner of the night.
Cate Blanchett, meanwhile, nabbed best actress for Blue Jasmine.
Take a look at the rest of the big winners at the 2014 Independent Spirit Awards!
Best Feature: 12 Years a Slave
Best Director: Steve McQueen, 12 Years a Slave
Best Screenplay: Bob Nelson, Nebraska
Best First Feature: Fruitvale Station
Best First Screenplay: Bob Nelson, Nebraska
John Cassavetes Award: This Is Martin Bonner
Best Female Lead: Cate Blanchett, Blue Jasmine
Best Male Lead: Matthew McConaughey, Dallas Buyers Club
Best Supporting Female: Lupita Nyong'o, 12 Years a Slave
Best Supporting Actor: Jared Leto, Dallas Buyers Club
Best Cinematography: Sean Bobbitt, 12 Years a Slave
Best Documentary: 20 Feet from Stardom
Best International Film: Blue Is the Warmest Color
Robert Altman Award: Mud
Piaget Producers Award: Toby Halbrooks and James M. Johnston
Someone to Watch Award: Shaka King, Newlyweeds
Truer than Fiction Award: Jason Osder, Let the Fire Burn