The David O.Russell-directed flick took home the award for Best Cast in a Motion Picture, beating out 12 Years a Slave, Dallas Buyers Club, August: Osage County and Lee Daniels' The Butler.
But the Steve McQueen-directed historical drama still received some love at the annual show, as breakout beauty Nyong'o nabbed the honor for Outstanding Performance by a Female Actor in a Supporting role for her work in 12 Years a Slave after losing the Golden Globe earlier this month to J.Law.
The Hollywood newbie thanked her costars and family as she accepted her award on stage, before recalling the moment she discovered she was cast in the film. "My dad was the first person I called when I got this role and I said to him, 'Daddy do you know Brad Pitt? I'm going to be in a movie with him. And he said, 'I don't know him personally, but I'm glad you got a job'—So am I so am I!'"
And so are we!
The next honor—the award for Best Supporting Actor—was presented to Jared Leto (and his magnificent head of hair), and despite now having received both the Golden Globe and the SAG award for his role in the AIDS drama, the humble 42-year-old hunk gushed over his fellow actors and dedicated his honor to those suffering from the disease during his acceptance speech.
"I would like to dedicate this very special honor to all the people that have lost their lives to this dreadful disease, to the people who are out there living with HIV/AIDs," he said. "To my fellow and far more talented nominees, I'm so honored to share this adventure with you, especially with the late and great James Gandolfini."
And of course, he gave an extra shout-out to costar Matthew McConaughey: "Matthew, all right all right all right, baby!"
Julia Louis-Dreyfus then filled the room with laughter when accepted her award for Best Female Actor in a Comedy series for her role in Veep after losing at the Golden Globes last week.
"I'd like to begin by thanking the members of the Hollywood Foreign Press for this Golden Globe," the six-time SAG award nominee quipped as she took the stage.
Then it was time for Modern Family's Ty Burrell to finally end Alec Baldwin's winning streak after the TV star dethroned the 30 Rock actor, who had previously taken home the trophy for Outstanding Performance By a Male Actor in a Comedy seven years in a row prior to Burrell's win.
Burrell's speech was almost as fabulous as the hilarious comedy on which he stars, as he proceeded to share amazing advice for aspiring actors.
"I know most of you out here tonight have read my book, Acting: How to Do It Good, but I thought maybe…I would just go back over my five simple steps to success," he said.
"1. Be born into a family that's never had an actor in it. That way they think everything you do is cooler than it actually is, thus giving you a false sense of confidence.
2. Use that false sense of confidence to woo and trap a spouse that is better than you and is willing to overlook the fact that you have no apparent skill set other than being a needy extrovert.
3. Have no skill set other than being a needy extrovert.
4. Use that lack of skill to fail over and over and over again until you stumble into a job written by Chris Lloyd, Steve Levitan and our entire writing staff. Also at that job, make sure your coworkers are the cast of Modern Family.
5. Um, have a knack for memorizing."
Isn't he the best?!
And as added cherry on top of Burrell's well-deserved win, Modern Family proceed to take home the award for Best Ensemble in a Comedy Series.
"We're going to make Sofia talk because America loves her and her boobs," Julie Bowen joked as the cast took the stage, accepting their third consecutive SAG.
Helen Mirren then took home the award for Best Female Actor in a TV Movie or Mini Series for her role in Phil Spector, giving props to pal Elisabeth Moss before hilariously complimenting her trophy's fabulous figure.
"I love this little guy. He's so sexy, isn't he? You know, sorta naked but not quite. Quite exciting," Mirren joked, and topped it off with, "I don't feel at all saggy. I feel quite perky, actually."
Like Jared Leto, Michael Douglas continued his post-Globes winning streak, nabbing the honor for Best Male Actor in a TV Movie or Mini Series for his portrayal of Liberace in Behind the Candelabra.
And similar to his speech last week, he gushed over his costar Matt Damon, while poking fun at their romantic relationship in the flick.
"Throughout the awards we've spoken about who's on top, who's on bottom, two-handers," Douglas deadpanned, "but Matt, I want to be serious right now."
"The truth is, and you know it, I am not here without Matt Damon. Matt Damon," he paused for applause, "had the courage to stand by early on for this part while...we had to wait for another year [to start shooting], and Matt was there. It's really the joy of acting and Matt, this is yours too, you know that. Thank you all."
And how could we forget Rita Moreno's amazing F-bomb she dropped while accepting her Lifetime Achievement Award at the age of 82?!
"I'm so f--king thrilled," she said. "I hope the man with the button was there on time."
Clearly, the West Side Story star is still full of spunk.
The award for Best Female Actor in a Drama Series then went to Downton Abbey's Maggie Smith before Breaking Bad proceeded to steal the award show spotlight.
"I won a SAG Award!" he sang to the delight of the crowd as he accepted his statue before recalling a few of the "crappy" jobs he worked before making it big as an actor.
"I loaded trucks downtown, coal, dust, dirt everywhere, every orifice. People yelling at you, 'Cranston, move faster! Work harder!' And the only thing that got me through was imagining, dreaming one day that I could actually make a living as an actor," he said. "That's what got me through. Thank god. We are the luckiest people in the world who say, 'I am an actor.'"
Breaking Bad also nabbed the statuette for Outstanding Ensemble in a Drama series, to which Cranston said, "What a way to go out in style, Breaking Bad!"
Matthew McConaughey and Cate Blanchett capped off the show with their Best Leading Actor wins for their roles in Dallas Buyers Club and Blue Jasmine, respectively.
The 44-year-old star, who lost a staggering 38 pounds to play a man diagnosed with HIV/AIDS, gave a head-scratching acceptance speech before Blanchett took the stage and threw some shade at McConaughey when she was told to wrap up her speech.
"I've been away from the film industry for a long time making theater...29 seconds?! Matthew McConaughey spoke about Neptune and I think I can have five seconds!" she huffed.
It was then American Hustle's turn to take home the top honor...
And now it's off to the Oscars!