And as we now anxiously await the arrival of her and husband Will Kopelman's bundle of joy, we also look forward to hearing what the 38-year-old actress has to say as her pregnancy moves along.
After all, Barrymore has frequently gushed about the joys of parenthood ever since (and even before!) daughter Olive was born back in September of 2012.
Naturally, this is the perfect time to look back on some of her more memorable mommy-related quotes...
"I can't wait until I have my children," Barrymore told Haute Living just prior to Olive's birth. "I love the idea that they don't have to do something that they have no interest in, that they can do something completely opposite if they want to. I will be so surprised if they don't want to do something involving food or wine or art, but I'll be OK with it. I just want to build fun, great things for my family."
"You have the highest highs and yet you're facing the biggest fear of, 'How do I keep someone alive?'" the new mom shared with People right after her daughter's arrival.
"I love the person who said, 'Parenting is like wearing your heart on the outside of your body.' It's the most beautiful, perfect analogy," Barrymore said to InStyle. "I have anxieties about how much I'd like to get it right, making sure I provide her with an environment that's safe, nurturing and loving. And silly and free, also consistent and grounding."
"My favorite thing about being a mom is just what a better person it makes you on a daily basis," she admitted to Good Housekeeping. "Every morning when I wake her up, the endgame is, Can I get her to smile? And that puts me in a good mood. It's definitely a different way to live—and a much better one."
"I had such an exposed childhood...I appreciate my journey, but I don't want that for my kid. Not any of it," Barrymore told Harper's Bazaar. "It has nothing to do with whether I liked my childhood. I really did. But as a parent, that isn't the childhood that I'd provide."
"I will absolutely instill in her that you cannot be ashamed of the journey that it took to get where you are if you are proud of yourself," she insisted while chatting with Oprah Winfrey on Oprah's Next Chapter.
"I always commit," Barrymore told Allure. "I want to be that kind of mother...I do everything in this life-or-death way," adding, "The only thing I've tried to get better at is starting to believe maybe it's not life or death. But the [level of] commitment hasn't changed or wavered."