The late-night host chatted (and joked) with her panel about the pop star's announcement on the Tuesday, Sept. 17 edition of Chelsea Lately.
The Grammy winner revealed earlier in the day that she inked a two-year deal to perform at Planet Hollywood Resort and Casino in Las Vegas.
"They are shooting for a cool hip club-like show," Handler said as the studio audience chuckled. "She doesn't want to move to Vegas because she doesn't want to take her children out of school, cause she's a great mother."
After a long pause, Handler added that Spears is "so good at being a mother."
Handler then wondered what the best timing is, career-wise, to go to Las Vegas to perform.
"You just have to decide, if you want to go in the beginning when things really are bad, or, you want to go at the end of the run when things are just really, really f--ked up."
And what about the reports that the singer vomited in a helicopter on the way to her Good Morning America appearance?
"Is this a real story?," Handler quipped. "She vomited on the helicopter? Why?"
We don't know either, Chelsea.
Tune into Chelsea Lately weeknights at 11 p.m. on E!