Sad international split news.
The actors met on the set of the 1996 French-language film L'appartement and tied the knot in 1999. They have two daughters together, 8-year-old Deva and 3-year-old Léonie.
The Italian-born Bellucci, who starred in The Passion of the Christ and the two Matrix sequels, told Grazia magazine back in April, referring to marriage, "We never know how long it will last."
"Today, it works, but in a year...I don't know," she said.
Around the same time, Cassel reportedly told Britain's Closer magazine, "My wife and me are very different animals. This is probably the key to our relationship after 18 years together...We don't seek other people's approval."
According to the Daily Mail, Bellucci is currently shooting a film in Serbia.
The 48-year-old beauty was on the cover of the February 2013 issue of Vanity Fair Spain, telling the magazine that she and Cassel owned homes in London, Rome and his native Paris, and were thinking of buying another in Brazil—and that they were together but maintained separate lives.
"I never get involved in the choice of his papers nor in mine," Bellucci said. "We are very independent, we live in different worlds: His friends are your friends, mine are different."