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Rob Lowe Plays President John F. Kennedy in Killing Kennedy—See the First Pic!

Killing Kennedy, Rob Lowe Kent Eanes/National Geographic Channel

Get an early look at Rob Lowe as President John F. Kennedy.

The 49-year-old actor will be playing the 35th President in the upcoming TV movie Killing Kennedy, based on the best-selling book of the same title by Bill O'Reilly and Martin Dugard.

In this newly released photo, the Parks and Recreation star is striking the famous Kennedy pose made famous in the former president's official portrait.

VIDEO: Check out Rob taking flight via jetpack

The film highlights the final years of JFK before his assassination by Lee Harvey Oswald (played by Will Rothhaar) in November 1963. The cast also features Ginnifer Goodwin as Jacqueline Kennedy and Michelle Trachtenberg as Marina Oswald.

"Just saw @ginnygoodwin as Jackie Kennedy in the sad and awful blood-stained dress. Extremely emotional," Lowe tweeted on Tuesday to his on-screen wife.

Goodwin wrote back, "Just saw Rob in JFK GLORY. Overcome!"

The two-hour docudrama will air on the National Geographic Channel in November, coinciding with the 50th anniversary of the President's death.

PHOTOS: See what other stars have played Kennedys

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