"He calls it trickery," the 44-year-old actress said. "He's constantly hiding behind drapes. And I'm constantly scared. It's like, it doesn't get old on me."
"Do that to him," DeGeneres urged. "He's not expecting it now."
Aniston replied, "OK, shh. I'm going to do that!"
Backstage at Ellen, Aniston tried to get in on the pranking herself by jumping out from behind a door at DeGeneres. Sadly, the trickery wasn't exactly successful.
"Let's talk about your failure backstage," DeGeneres quipped. "It looked like you were running from a spider. Had you not ever scared anyone before?"
Aniston laughed, "That was really bad."
Check out Aniston's failed prank below!