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Seth MacFarlane, Emilia Clarke

AKM-GSI

It looks as if Seth MacFarlane and Game of Thrones star Emilia Clarke are no longer playing the game of love.

At least not with each other.

E! News has learned that the 39-year-old Family Guy funnyman and the 25-year-old actress have parted ways.

"They are no longer dating," a source tells E! News. "It was really a location challenge. She has been in Europe shooting Game of Thrones and he is based in California, so it was hard to make it work despite the distance. They have remained friends."

It was first revealed they were an item when the two were spotted getting cozy at the HBO Emmy afterparty at the Pacific Design Center in West Hollywood last September.

MacFarlane most recently hosted this year's Oscars while Clarke will soon be seen on Broadway in Breakfast at Tiffany's.

A rep for MacFarlane could not be reached for comment.

—Reporting by Melanie Bromley