And now comes word from a certain feline friend.
Of course, MacFarlane's pal with paws was just one of many who tuned in to watch the guy lead Hollywood's biggest night. The 2013 Oscars brought in 40.3 million viewers, up from the 2012 Oscars' 39.3 million.
But despite such numbers, the Family Guy creator insists he won't be back for an encore.
When asked by a Twitter follower if he would host again should producers approach him for a redux, MacFarlane replied: "No way. Lotta fun to have done it, though."
No word yet from his cat on that decision.