The Heat costars, joined by Sandra's son, Louis, and Melissa's husband, Ben Falcone, appeared to be enjoying themselves during their day at Disneyland.
Earlier this month, Sandra and Louis, 2, had a playdate with Melissa and her daughters Vivian, 5, and Georgette, 2, at the Mike & Molly star's home.
Sandra and Melissa "really became the best of friends," Heat director Paul Feig told E! News. "Their chemistry was so quick and good right off the bat."