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Danny DeVito, Rhea Perlman

SGranitz/WireImage

One of Hollywood's seemingly inseparable couples is calling it quits.

Danny Devito and Rhea Perlman have announced they have separated after more than 30 years of marriage, the Always Sunny in Philadelphia star's rep tells E! News.

The twosome first got to know each other when both were coming up in the TV world, and were already a couple when Perlman landed one of her first notable roles as Zena, the girlfriend of DeVito's character Louis DePalma on Taxi, before she shot to fame as sarcastic waitress Carla Tortelli on Cheers.

The diminutive pair tied the knot back on Jan. 28, 1982, after living together for 11 years. They have three children, 29-year-old Lucy, 27-year-old Grace and 25-year-old Jacob.

A rep for Perlman was unavailable for comment.