The supercouple welcomed a son and a daughter Saturday evening at the seaside Fondation Lenval in Nice, the actress' obstetrician tells E! News.
Twins Knox Leon and Vivienne Marcheline were delivered via cesarean section about 6 p.m. local time.
"Brad and Angelina are extremely happy and everything went perfectly," Dr. Michel Sussmann tells E! News. "Both of the babies are adorable and in excellent health and everyone's content and getting some much deserved rest.
"[Brad, Angelina and the twins] are all tired but very, very happy."
Knox arrived first and weighed 5 pounds, per Sussmann; Vivienne followed at 5.02 pounds, per a statement from the hospital.
Pitt was on hand to witness the womb exodus, which took place earlier than expected (conventional wisdom had the C-section taking place this Tuesday). Sussmann told the Associated Press the procedure was pushed up "for medical reasons," but declined to elaborate.
Jolie should be allowed to leave within a few days.
There's been no official comment from the couple's camp.
The Oscar-winning actress checked into her $500-per-night private room-with-a-view nearly two weeks ago for some prescheduled R&R.
So, the world stood by, as Jolie grew increasingly uncomfortable behind windows coated with paparazzi-blocking insulation and an Angie impostor happily modeled her expansive tummy through the window of her own room for the looky-loos down below.
"Any pictures released are either posed fakes set up by paparazzi or they are pictures of other patients," the hospital said in a statement Wednesday. "We hope this is clearly understood out of respect for all patients in this clinic."
Well, this clinic wasn't caring for just any patient—as far as the media were concerned, at least.
An international cordon of shutterbugs dutifully chronicled hospital visits from Pitt and their kids and Jolie's brother, James Haven, and waited for word of that inevitable first contraction, even after Sussmann announced that she might not deliver until mid-July.
The actual arrival comes weeks after it was erroneously reported that Jolie and Pitt had welcomed twin girls, Isla Marcheline and Amélie Jane, named in honor of the A-listers' own parents (Jolie's late mother was named Marcheline; Pitt's is Jane).
Earlier Saturday, reports surfaced indicating Jolie had given birth to twin girls, but a hospital spokeswoman said the stories had "wrong information."
Meanwhile, the ever-expanding clan—which, along with the newest additions, includes Maddox, 6; Pax, 4; Zahara, 3; and Shiloh, 2—have been hunkered down for the past couple months at their 1,000-acre chateau in the south of France. The other children, who have been under the care of Haven and an army of nannies, are expected to meet their new siblings on Sunday.
And judging by the 32-year-old mother of six's take on pregnancy, Knox and Vivienne may not be the last Jolie-Pitt progeny to be welcomed to the fold.
"I love it," a pre-popped Jolie said in the July issue of Vanity Fair of being pregnant. "It makes me feel like a woman. It makes me feel that all the things about my body are suddenly there for a reason.
"It makes you feel round and supple, and to have a little life inside you is amazing."
And two lives, while no doubt taxing, was even better for Jolie, thanks in large part to her 44-year-old better half.
"I'm fortunate," she said of partner Pitt. "I think some women have a different experience depending on their partner. I think that affects it. I happen to be with somebody who finds pregnancy very sexy. So that makes me feel very sexy."
Let the countdown for No. 7 begin.
(Originally published July 12, 2007 at 11:35 p.m. PT.)