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    Is George Clooney a Sure Thing for the Best Actor Oscar? You Can Bet on It!

    George Clooney, Golden Globes Paul Drinkwater/NBC

    George Clooney's the man to beat in the Best Actor category this year.

    His turn in The Descendants has him as the odds-on favorite—5-6, specifically—to win the award, according to the Wynn Las Vegas' Sports and Racing Operation.

    But who might be looking to give him some real competition?

    MORE: So What Are Ben Stiller's Oscar Chances Really?

    The Artist's Jean Dujardin, that's who. The French actor has quietly—really quietly— made a big impression on critics and Oscar voters alike. His performance as a silent film star at the dawn of the talkies has him polling at even money.

    Among the lead actresses, it's a close race between The Help's Viola Davis and The Iron Lady's Meryl StreepWynn has Davis at even odds and Streep 6-5. Fans of The Girl With the Dragon Tattoo shouldn't get their hopes up too high: Rooney Mara is a longshot at 50-1.

    In the supporting categories, Christopher Plummer is a near-lock at 1-9 for his work in Beginners while Octavia Spencer is expected to clean up in the supporting actress category with a 1-5 chance.

    MORE: Oscar Snub Party! Patton Oswalt & Albert Brooks Tweet Hilarious Guest List of Passed-Over Performers

    As for Best Picture, it's The Artist's trophy to lose at 2-1. That's followed by The Descendants at 7-1, The Help at 9-1 and Hugo, which has the most Oscar nominations, given 10-1 odds. 

    Wynn's odds are similar with those set by the sports gambling site, Easy Odds.

    Now if only someone could tell us the odds the Oscar ceremony will run long again?

    PHOTOS: 2012 Oscars Cheat Sheet!

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