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Reese Witherspoon vs. Chelsea Handler: Watch a Sneak Peek of Their Showdown!

Everybody loves Reese Witherspoon, right? Well, almost everybody.

"You know, Chelsea. I'm super excited to give you your award tonight. These guys did an amazing job," the Oscar winner tells Chelsea Handler after collaborating with the Chelsea Lately staffers on a speech she's going to give at a Women in Television event.

"Ooh, that reminds me, I made a little something to say thank you for all your hard work. I'll be right back," says Reese.

MORE: Cocky James Van Der Beek Pulls Celebrity Rank on After Lately

"Oh my God, she's driving me crazy," moans Chelsea after the actress has left the room. "You guys were right the last time. She is so awful."

"What are you talking about?" asks show writer Heather McDonald. "Reese is like a little slice of wonderful."

"No, she's like a big slice of pain in my ass," snaps Chelsea. "I should have asked Rosie O'Donnell to present me with my award. She's a mess."

Ouch!

To see how it all ends, and for more After Lately clips, tune in to E! News on Thursday at 7 and 11:30 p.m.

PHOTOS: Just Another Day in After Lately Hell

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