While rumors had been running rampant since January that the Pirates of the Caribbean star and his longtime love were on the outs, a rep for Depp told E! News today that the two "have amicably separated."
Let's take a moment to look back at their nearly 14-year romance...
1993: Depp and Paradis are introduced to each other at a mutual friend's house in France.
1998: Depp, back in France working on Roman Polanski's film The Ninth Gate, spots Paradis in a hotel lobby. The two recall meeting years earlier. Soon after, they begin dating.
May 27, 1999: Depp and Paradis welcome their first child together, daughter Lily-Rose.
Nov. 16, 1999: Paradis joins Depp as he receives a star on the Hollywood Walk of Fame.
April 9, 2002: Paradis gives birth to the couple's second child, a son, John, but nicknamed Jack.
Feb. 24, 2004: Depp, a Best Actor nominee for Pirates of the Caribbean: The Curse of the Black Pearl, escorts Paradis to the 76th Annual Academy Awards.
Sept. 16, 2005: The rock-solid relationship is on full display as Paradis watches Depp immortalize himself during the Hand and Footprint ceremony at Grauman's Chinese Theatre in Hollywood.
March 2007: Depp and Paradis reveal daughter Lily-Rose is "doing much better" after being discharged from a London hospital for an undisclosed illness.
May 2010: Depp and Paradis head to the south of France for the Cannes International Film Festival.
December 2010: The low-profile family makes a rare public appearance by going to a Dolphins football game in Miami.
Jan. 6, 2012: Reports begin to surface that Depp and Paradis are on the outs, with Radar citing a source that "their relationship is heading toward the end."
Jan. 15, 2012: Depp attends the Golden Globes without Paradis.
Jan. 18, 2012: People reports Depp and Paradis are currently living "separate lives," pointing out that the couple have not appeared together on a red carpet in over a year.
Jan. 19, 2012: Paradis spotted shopping solo in Paris.
Jan. 24, 2012: While promoting her new movie, Café de Flore, Paradis denies the breakup rumors. "Yes it's false! Of course it's false!" she tells a French television program.
May 22, 2012: A source tells E! News that Depp is "trying to work it out" with Paradis. "For the first time in a long time, he is talking about her," says the source. "They both want to make it work."
June 19, 2012: Depp's publicist tells E! News that the actor and Paradis "have amicably separated," asking everyone to "please respect their privacy and, more importantly, the privacy of their children."
(Originally published on Jan. 18, 2012 at 1:38 p.m. PT)