During the Descendents premiere Tuesday night, E! News' Giuliana Rancic caught up with Hollywood's most eligible bachelor (well, kinda) to talk about something much lighter than recent topics (but maybe not as sexy).

George Clooney gave his two cents on pal Brad Pitt's shocking plan to put his acting career to bed in three years...

"I hope he doesn't," the Cloonster told us.

"I'd like to work with him again. I sorta don't see it happening. He's at the peak of his career."

(Clooney might be clairvoyant. Since dropping the retirement bombshell, Pitt has backed off an exact date for calling it quits. At a press conference in South Korea yesterday promoting Moneyball, Pitt told reporters, "I wasn't putting an exact deadline on my expiration date. But I see it coming. I have other interests.")

As for retiring himself, Clooney says he thinks about it "all the time."

But he's joking, folks.

Now, can we get that next Clooney-Pitt movie in the pipeline, please.

For more of the exclusive interview with Clooney, including deets on his holiday plans, updates on his romance with Stacy Keibler and whether fatherhood is in his future, tune in to E! News tonight at 7 p.m. and 11:30 p.m.

PHOTOS: Ryan Gosling vs. George Clooney: Who's Sexier?

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