The sad news was announced this morning by fellow comic Jim Norton on the Opie and Anthony Show.
The worst part?
Norton doesn't know if O'Neal is going to fully recover.
"We don't know how he is. We don't know how he's going to be," said Norton. "I didn't want to do this by myself. I wish we had more news for you."
Norton added that he made the announcement onair becase "we wanted it to come from us."
A statement was also posted on Opie and Anthony's Facebook page, which allows fans to send the comic well wishes.
"Our close friend Patrice O'Neal suffered a stroke last week," the statement reads. "Please respect his family and their request for privacy. An email has been set up for fans to send him well wishes and his family will make sure he gets them. You can write to LoveForPatrice@gmail.com. When we have an update on his condition, we will let you all know."
Get well, Patrice!